นโยบายงานวิจัย /จรรยาบรรณนักวิจัย /ระดับคุณภาพบทความวิจัยตีพิมพ์ /ระดับคุณภาพผลงานวิชาการ /แหล่งทุน /ดาวน์โหลด /ฐานข้อมูลวิจัย /วิเคราะห์-สังเคราะห์งานวิจัย /ลิขสิทธิ์ /ข่าว


An approach for determining the accelerated stability during the optimization of ellagic acid loaded transfersomes using the computer program

Author

-

Sureewan Duangjit,Pattaraporn Ruangkarnjanapaisarn,Thanattha Inta,WandeeRungseevijitprapa


Journal

- Isan Journal of Pharmaceutical Sciences

Volume

- 11

Year

- 2016

Publication type

- Research article (National)

Page list

- 112-123

Abstract

   

Introduction= In the development of pharmaceutical products, the objective of the formulation optimization is to design and develop the proper dosage form that results in higher efficacy, safety and stability. The formulation efficacy and safety can be assessed during the optimization process. The evaluations for the formulation efficacy and safety saved time more than the formulation stability study. The stability evaluation takes a lot of time for the long term stability study, so several researchers have chosen the accelerated stability instead. However, at least 2-3 months were spent for the accelerated stability evaluation. The objective of this study was to minimize the time and measurement samples for determining the accelerated stability during the optimization of ellagic acid loaded transfersomes using the computer program. Method= Ten model formulations of transfersomes consisting of a constant percentage of phosphatidylcholine, ellagic acid and various molar percentages of cholesterol and oleic acid from 0-90%mol. The transfersome formulations were experimentally prepared and investigated. To evaluate the stability, all transfersome formulations were kept in the stability chamber at 45°C for 12 h and the refrigerator at 4°C for 12 h, for3 cycles. The sample was collected and measured through the physicochemical characteristics, e.g. vesicle size, polydispersity index (PDI), surface charge and entrapment efficiency. The Design Expert® was applied for determining the accelerated stability during the formulation optimization. Results= The results suggested that the computer program was a powerful methodfor estimating the stability of the formulation during the optimization process. Moreover, the Design Expert® obviously showed the relationship between the formulation components and the formulation stability. Conclusion= The utilization of the computer program in this study was succeeded in showing the feasibility of the approach for determining the accelerated stability during the formulation optimization with the minimization of time and measurement samples.

 


Keywords

    Transfersomes, Stability evaluation, Accelerated stability, Optimization